The trick to aging gracefully is to enjoy it. But how do we enjoy it with inevitable age-related diseases? Recent studies have found that the benefits of berberine may be related to combating aging and age-related diseases. Some studies even proclaim that it has the same effects to lowering blood sugar levels and reducing insulin levels as metformin.

Benefits of Berberine

  • Targets Insulin Resistance and Helps Treat Diabetes: berberine activates a protein called AMPK which sensitizes your body to insulin, activates fat-burning enzymes, and helps reduce body fat stores.
  • Increases Mitochondrial Density and Boosts Metabolism: berberine increases the number of mitochondria which helps with increasing metabolism that can reverse the damage done by high sugar/high-fat diets that made our mitochondria run slowly and produce energy less efficiently.
  • Induces Brown Fat Break Down & Increases Fat Break Down Overall: berberine enhances brown fat which increases body temperature to burn more fat and increases baseline metabolism, which increases weight loss.
  • Lowers Inflammation in Fat & Liver Cells: berberine helps reduce general inflammation and hepatocyte inflammation (liver cell inflammation).
  • Treats GI-Related Issues due to Antibacterial & Antifungal Effects: berberine can help lower intestinal inflammation in cases of Small Intestinal Bacterial Overgrowth (SIBO) or Small Intestinal Fungal Overgrowth (SIFO).
  • Can be Used in Conjunction with Other Medications to Increase Effectiveness: berberine has been combined with metformin to increase weight loss effects, reducing insulin and managing blood sugar levels.


How does this help with aging?

  • AMPK has been referred to as our metabolism’s “master switch”, which helps with weight loss and even fighting cancer.
  • Due to berberine’s ability to activate AMPK, it helps create more efficient cell energy to boost metabolism, energy, heat, and burn fat.
  • AMPK is considered a longevity pathway like a communication channel between cells and the body that can help offset age-related disorders (diabetes, obesity, fatty liver, gut health issues, etc.).
  • Due to the master switch being activated, your cell has more power to fight off infection, bacteria, and fungus to help protect you from disease.


In conclusion, berberine can be a beneficial supplement, but the research is still determining if this is a safe alternative to treat diabetes or other diseases. We recommend talking to your physician to see if this would be an excellent supplement to add to your diet.


How to use Berberine to Boost Weight Loss, Lower Blood Sugar & More

Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation

Berberine the Super Anti-Aging Antioxidant

The Longevity Pathways – How to Live a Happy, Healthy and Long Life

Metformin Or Berberine?

Role of inflammatory response in liver diseases: Therapeutic strategies

Is berberine a safe alternative treatment for diabetes?